Zack sprains his knee before the big basketball game, and while in hospital learns that Lisa is a part-time candy-striper. However, he also learns that he will need surgery to repair his knee and worries that it may go wrong.
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After Zack accidentally undergoes genital reassignment surgery, he pledges his life to living as a woman — this is never addressed again moving forward, however fans of the show lashed out against the positive portrayal of gender fluidity.